钙卫蛋白对儿童非IgE介导的牛奶蛋白过敏的诊断价值

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[中图分类号]R174 [文献标识码]A

[文章编号]1673—593（05）07—0001-06

Diagnostic value of calprotectin in children with non-IgE-mediated cow's milk protein allergy

HE Xiaobao1²，DU Chunyan1，LIN Yan1，YANG Yang1，WANG Yujuan1 ， SONG Lijia1，LI Yuanxia²，SHANG Lei，JIANG Xun1

（1.Department of Pediatrics，Tangdu Hospital，The Second Affiliated Hospital of Air Force Military Medical University，

Shaanxi Xi'an71oo，China;2.SchoolofMedicine，Yan'an University，Shaanxi Yan'an7160oo，China;3.Departmentof

Health Statistics，Facultyof Preventive Medicine，Air Force MilitaryMedical University，Shaanxi Xi'an71oooChina）

[AbstractObjectiveToinvestigatethediagnosticvalueoffecalcalprotecti（FC）intheearlyidentificationofnon-IgEmediated cow's milk protein alergy（non-IgE-CMPA）.MethodsFrom May 2023 toNovember 2024，65childrenwith suspected non-IgECMPA wereenroledintheoutpatientclinicoftheSecondAfliated HospitaloftheAirForceMedicalUniversity，ofwhich3were diagnosed with non-IgE-CMPA.There were 35casesof non-cow’smilk protein alergy.TheFClevelsofthetwogroups were compared，andthegenderge，materaldliveryhistory，ndmatealalergyistoryofthechdrenineachgroupererorded. Multivariatelogisticregressonwasusedtoanalyzetheinfluencingfactorsofnon-IgE-CMPA.Thereceiveroperatingcharacteristic （ROC）curve analyzedthediagnostic valueofFCfornon-IgE-CMPA.Results There wasastatisticallysignificant diference in fecal calprotectin levels between the two groups （t=4.624，P<0.001） ，the children were born by cesarean section OR=6.206，95%CI ： 1.377-27.981），and the mother had a history of allergies （OR=5.732，95%CI：1.147-28.640） was an independent risk factor for non-IgE-CMPA （ P<0.05 ，the area under the curve of FC in the diagnosis of non-IgE-CMPA was O.792，and the sensitivity and specificity were 73.3% and 85.7% when the cut-off value of FC was 62.56ng/mL .Conclusion FC detection may have certain diagnosticvalueintheearlydentificationofnon-IgE-CMPA，andthedetectioncostisow，theoperationissimple，anditisuitable for pediatric outpatient promotion.

[Keywords]milk protein allergy;non-IgE mediated allergy;fecal calprotectin;children

牛奶蛋白过敏（cow'smilk proteinallergy，CMPA）是婴儿和3岁以下儿童最常见的食物过敏[。（剩余10141字）