肝硬化门静脉高压伴自发性门体分流的诊治现状与展望

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摘要: 肝硬化是各种慢性肝病的终末阶段,主要的临床表现为门静脉高压,其发生可导致自发性门体分流(SPSS)。SPSS在临床上多见,并且与患者预后息息相关。本文总结了近年来研究肝硬化门静脉高压伴SPSS的临床意义、研究中所存争议、当前治疗现状以及未来展望与挑战,为门静脉高压的规范化诊治提供参考。

关键词: 肝硬化; 高血压, 门静脉; 自发性门体分流

基金项目: 西安市科技计划项目(23YXYJ0180); 西安医学院创新团队(2021TD15); 佑安肝病感染病专科医疗联盟科研专项基金(LM202028)

Diagnosis and treatment of cirrhotic portal hypertension with spontaneous portosystemic shunt: Current statusand prospects

CHEN Yaxin 1,2 , GUO Wen 1,2 , LIU Kaige 1 , LI Qian 1 , ZHANG Mingxin 1

1. Department of Gastroenterology, The First Affiliated Hospital of Xi’an Medical College, Xi’an 710077, China; 2. GraduateSchool of Xi’an Medical University, Xi’an 710021, China

Corresponding author: ZHANG Mingxin, zmx3115@xiyi.edu.cn (ORCID: 0000-0002-3945-3387)

Abstract: Liver cirrhosis is the terminal stage of various chronic liver diseases, with the main clinical manifestation of portalhypertension, which can lead to spontaneous portosystemic shunt (SPSS). SPSS is very common in clinical practice and is closelyassociated with the prognosis of patients. This article summarizes the recent studies in the clinical significance of cirrhotic portalhypertension with SPSS, the controversies in studies, and the current status and future prospects and challenges of treatment, inorder to provide a reference for the standardized diagnosis and treatment of portal hypertension.Key words: Liver Cirrhosis; Hypertension, Portal; Spontaneous Portosystemic ShuntResearch funding: Xi’an Science and Technology Plan Project (23YXYJ0180); The Innovation Team of Xi’an MedicalUniversity (2021TD15); Youan Specialist Medical Alliance for Liver and Infectious Diseases Special Fund (LM202028)

在肝硬化患者中,门静脉高压可导致自发性门体分流(spontaneous portal system shunt,SPSS)发生。(剩余17727字)

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