补阳还五汤治疗周围神经病理性疼痛的研究进展

关键词：补阳还五汤；周围神经病理性疼痛；带状疱疹后遗神经痛；痛性糖尿病性周围神经病变；三叉神经痛；痛性神经 根病变；综述

中图分类号：R289.5 文献标志码：A 文章编号：1007-3213（2025）06-1538-07

DOI：10.13359/j.cnki.gzxbtcm.2025.06.036

Research Progress on Buyang Huanwu Decoction in the Treatmentof Peripheral Neuropathic Pain

CHEN Zijia'²，CHEN Kaihao'²，WANG Dongmei² （1.Schoolof Traditional Chinese Medicine，Southern Medical University，Guangzhou 51O515Guangdong，China; 2.Dermatology Hospital of Southern Medical University，Guangzhou 51O091 Guangdong，China）

Abstract：Peripheral neuropathic pain（PNP） is a chronic pain conditioncaused by the primary damage or the dysfunctionof the peripheral nervous system.The incidence of PNP is relatively highand increases withage，and PNP has significant impact on patients’quality of life.Common syndromes associated with PNP include postherpetic neuralgia，painful diabetic peripheral neuropathy，trigeminal neuralgia，and painful radiculopathy. Buyang Huanuu Decoction，originating from Wang Qingren’sYi LinGai Cuo（Corrections on the Errors of Medical Works during） the Qing Dynasty and mainly having the actions of replenishing qi and promoting blood circulation， removing stasis and unblocking colaterals，is primarily known as arepresentative formula for treating strokedue to qi deficiency and blood stasis.Nowadays，modern practitioners have extended its application in treating various multi-system diseases in internal medicine.This paper systematically reviewed clinical studiesand pharmacological mechanisms of Buyang Huanwu Decoction in treating PNP over the past 2O years.The results indicated that the combination of herbs in Buyang Huanwu Decoction has multi-component，multi-target，and multi-pathway effects on repairing nerve damage， nourishing nerves， promoting nerve regeneration， and alleviating neuropathic pain. Buyang Huanwu Decoction shows significant efcacy in treating PNP syndromes caused by neuropathic damage resulting fromvarious etiological factors.Thisarticlereviewedboth clinical observationand basic research on Buyang Huanwu Decoction in treating PNP，aiming to provide references for the clinical treatment of PNP and to expand the clinical applications of Buyang Huanwu Decoction.

Keywords： Buyang Huanwu Decoction；peripheral neuropathic pain（PNP）；postherpetic neuralgia；painful diabetic peripheral neuropathy；trigeminal neuralgia；painful radiculopathy；review

神经病理性疼痛（neuropathicpain，NP）是慢性疼痛的主要类型，可分为中枢性NP和周围性NP，顽固的NP是医学界尚未解决的临床难题。（剩余12574字）