神经肌肉疾病患者睡眠呼吸障碍的诊治进展

【摘要】 神经肌肉疾病易于合并睡眠呼吸障碍，早期诊断和干预睡眠呼吸障碍对慢性神经肌肉疾病的管理具有重要价值。本文回顾分析了神经肌肉疾病患者合并睡眠呼吸障碍的机制、临床表现、诊断方法及治疗进展。近年来虽然便携式睡眠监测设备不断发展，但对此类患者的诊断价值尚未完全明确，仍需要更多的关注和研究。

【关键词】 神经肌肉疾病；睡眠呼吸障碍；多导睡眠监测；便携式睡眠监测；无创正压通气；诊断；治疗

【中图分类号】 R 746 R 563.8 【文献标识码】 Ａ DOI：10.12114/j.issn.1007-9572.2022.0266

丁啟迪，曹照龙，韩芳. 神经肌肉疾病患者睡眠呼吸障碍的诊治进展［J］. 中国全科医学，2022，25（33）：4203-4206 .［www.chinagp.net］

DING Q D，CAO Z L，HAN F. Advances in the diagnosis and treatment of sleep-disordered breathing in neuromuscular disease［J］. Chinese General Practice，2022，25（33）：4203-4206.

Advances in the Diagnosis and Treatment of Sleep-disordered Breathing in Neuromuscular Disease DING Qidi，CAO Zhaolong，HAN Fang*

Department of Respiratory and Critical Care Medicine，Peking University People's Hospital，Beijing 100044，China

*Corresponding author：HAN Fang，Professor，Chief physician；E-mail：hanfang1@hotmail.com

【Abstract】 Sleep-disordered breathing（SDB） occurs frequently in neuromuscular disease（NMD） patients，and early diagnosis and treatment of which are of great value in the management of NMD. We reviewed the advances in pathogenesis，clinical manifestations，diagnostic and treatment modalities of SDB in NMD. It is noteworthy that although the development of portable sleep monitoring devices is ongoing，the diagnostic value of them for such patients has not been fully clarified，and more attention and further research are still needed.

【Key words】 Neuromuscular disease；Sleep-disordered breathing；Polysomnography；Portable monitor；Noninvasive positive pressure ventilation；Diagnosis；Treatment

神经肌肉疾病（neuromuscular disease，NMD）是以神经肌肉功能受损、肌力减退、运动耐力下降为主要表现的一大类疾病，主要累及下运动神经元，如脑干运动神经元、脊髓前角、神经根、神经肌肉接头、周围神经等［1］。（剩余11369字）