基于环状RNA靶点探讨中医药治疗结直肠癌的分子互作与干预策略

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关键词：结直肠癌；环状RNA；中医药治疗；分子互作；靶向干预；研究进展中图分类号：R285.5文献标志码：A 文章编号：1003-9783（2025）12-2202-09doi：10.19378/j.issn.1003-9783.2025.12.019

Exploring Molecular Interactions and Intervention Strategies of Traditional Chinese Medicine for Colorectal Cancer Based on circRNA Targets

CAO Xinyue1，LI Xunuo1， ZHANG Mingshan²，WANG Yiyun1，GAO Minghuang1，WANG Qi .1 ，YU Liangwen'， LIU Jinman’（1.Science and Technology Innovation Center，Guangzhou Universityof Chinese Medicine，Guangzhou 510405 Guangdong， China；2.Guangzhou University of Chinese Medicine，Guangzhou 510006 Guangdong，China; 3.Central Laboratory，Affiliated Jiangmen TCM HospitalofJinan University，Jiangmen 529099 Guangdong，China）

Abstract：Colorectal cancer，a highly prevalent malignant tumor worldwide，involves complex molecular regulatory networks in its pathological progression.Circular RNAs （circRNA），as novel non-coding RNA molecules，participate in the pathogenesis and progression of colorectal cancer through miRNA sponging，proteininteractions，and translational functions，therebyprovidingnew targets forcancertherapy.Thisarticle systematically elucidates the biogenesis，functional characteristics，and dysregulation mechanisms ofcircRNAs incolorectalcancer，withafocused reviewon theresearch advances in traditional Chinese medicine（TCM）regulating circRNA for colorectal cancer treatment.It explores the molecular interaction paterns bywhich TCMcompounds，single herbs，and active components intervene in colorectal cancer through the regulation of circRNA networks，and proposes a threedimensional interaction model of“TCM component-circRNA-target protein".The review also highlights future research directions integrating single-cellsequencingand chemical biologyprobes todecipher dynamic regulatory networks.This work provides atheoretical basis fordeveloping precision TCM therapeutic strategies targeting circRNA，contributing to the deep integration of traditional medicine and modern molecular targeted therapies.

Keywords：colorectal cancer；circular RNA；traditional Chinese medicine therapy；molecular interactions；targeted intervention； research progress

结直肠癌作为全球重大公共卫生问题，据流行病学数据-2显示，其全球年新增病例约114万例，相关死亡病例达57万例，现已成为全球第五大常见恶性肿瘤。（剩余18367字）