妥拉唑林联合一氧化氮吸入治疗新生儿持续肺动脉高压的效果及其对血清PGI2和PDE3A的影响

打开文本图片集

[中图分类号]R174 [文献标识码]A [文章编号1673—5293（2026)02-0092-06

Efficacy of tolazoline combinedwith inhaled nitric oxidein treatment of persistent pulmonary hypertensionof newbornand its effectsonserum PGI2 and PDE3A

LIULei,ZHANG Tao,WANGKai (Department of Neonatology,Zhengzhou Central Hospital Af filated to ZhengzhouUniversity,HenanZhengzhou45OoO7,China）

[Abstract]ObjectiveToanalyzetheeficacyoftolazolinecombinedwithinhalednitricoxide（NO）inthetreatmentofpersistent pulmonary hypertension of newborn（PPHN）anditsefectsonserum prostaglandinI2（PGI2）and phosphodiesterase 3A (PDE3A).MethodsAtotalof125newbornswithPPHNtreatedinour hospitalfromJuly2021toJuly2024 wereenroledand divided into the NO inhalation group Ωn=62 ）and the combination group ( Δ⋅n=63 ）according to different treatment regimens.The NOinhalationgroupreceivedinhaledNOtherapywhilethecombinationgroupreceived tolazoline inadditiontoinhaledNO.Thet test and χ2 test were used tocompare clinical eficacy and pulmonary artery pressre indices,including pulmonary artery systolic presure(PASP)，pulmonary artery mean pressure (PAMP),and pulmonary artery pressure (PAP),betwee the two groups. Arterial blood gas parameters,including oxygen saturation ( SaO2 ),partial pressure of carbon dioxide in arterial blood ( ⋅PaCO2 ）， and partial pressure of oxygen in arterial blood ( ΔPaO2 ),were also compared. In addition，differences in serum PGI2 and PDE3A levels,mechanicalventilationtime,oxygentherapytime,andlengthofhospitalstaywereanalyzed.ResultsThetotalclinical effective rate in the combination group (96.83% ）was significantly higher than that in the NO inhalation group (82.26% ） (X2= （20 7.116,P2 and PaO2 levels in the combination group were significantly higher than those in the NO inhalation group ( t=3,793 and 7. 642,respectively, P2 （204 level in the combination group after treatment was significantly lower than that in the NO inhalation group (t=18.181,P

[Keywords]noborn;persistentpulmonaryhypertension;tolazoline;itricoxide;eficacy;prostaglandinI2;phosphodiesteraseA

新生儿持续肺动脉高压（persistent pulmonaryhypertensionofnewborn，PPHN)是指胎儿型循环过渡到成人型循环的过程出现障碍，新生儿肺动脉阻力持续性增高，可诱发严重的低氧血症，是较为常见的一种危重症[1]。（剩余14408字）