胰十二指肠切除术后胃排空延迟的发病机制及危险因素

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摘要:胃排空延迟(DGE)为胰十二指肠切除术(PD)后常见并发症,其发病原因与机制目前国内外尚未完全阐明,但绝大多数患者可在一般对症治疗后痊愈。笔者对PD术后DGE发生的危险因素及病理生理机制进行综述,旨在为临床有效防治PD术后DGE提供参考。

关键词:胰十二指肠切除术; 胃排空; 胃肌轻瘫

基金项目:国家自然科学基金(U20A20360); 吉林省科技厅项目(20200603001SF)

Pathogenesis of delayed gastric emptying after pancreaticoduodenectomy and related risk factors

WANG Zhe, LYU Xing, YU Jiaao, SUN Xiaodong, LI Ting, LYU Guoyue. (First Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun 130021, China)

Corresponding author:LYU Guoyue, lvgy@jlu.edu.cn (ORCID:0000-0002-9778-5080)

Abstract:Delayed gastric emptying (DGE) is a common complication after pancreaticoduodenectomy (PD). The etiology and pathogenesis of DGE have not been fully elucidated in China and globally, and the majority of patients can be cured after general symptomatic treatment. This article reviews the risk factors and pathophysiological mechanisms of DGE after PD, in order to provide a reference for the effective management of DGE after PD in clinical practice.

Key words:Pancreaticoduodenectomy; Gastric Emptying; Gastroparesis

Research funding:National Natural Science Foundation of China(U20A20360); Science and Technology Department of Jilin Province(20200603001SF)

胃排空延迟 (delayed gastric emptying, DGE)又称为胃瘫综合征,为胰十二指肠切除术(pancreaticoduodenectomy, PD)术后常见并发症之一[1],2007年国际胰腺外科学术委员会(ISGPS)[2]首次提出,可基于临床症状的严重程度将DGE分为A、B、C三个等级,后两级统称为临床相关性DGE,为临床常用诊断标准。(剩余17207字)

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