禽流感病毒感染进程中宿主细胞线粒体自噬通路的应答与调控机制研究进展

打开文本图片集

中图分类号：S855.3 文献标志码：A 文章编号：1001-411X（2026）03-0361-08

Research progress on the response and regulatory mechanisms of host cell mitophagy pathway in the process of avian influenza virus infection

REN Tao，WU Yaotang， WEI Wanqi， LIN Qiuyan， CHENLibin （Key Laboratory of Animal Vaccine Development， Ministryof Agriculture and Rural Affairs/National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control， PR China/Key Laboratory of Zoonosis Prevention and Control of Guangdong Province/College of Veterinary Medicine， South China Agricultural University， Guangzhou 510642， China）

Abstract： The frequent outbreaks of avian influenza have caused huge economic losses to the poultry industry. Its pathogen， avian influenza virus （AIV），can infect not only birds， but also some subtypes can infect humans and other animals crossing species barrers， which poses a continuous threat to global biosafety. Autophagy， as a highly conserved degradation process that maintains cellular homeostasis， plays a dual role （both antiviral and proviral） in viral infections.Research has shown that AIVcan actively intervene in autophagic flux through viral proteins such as NS1，M2 and PB1-F2 to obtain the membrane structures required for self-replication and evade host immune monitoring， especially targeting mitophagy processes. In addition， virus-induced mitochondrial dysfunction not only leads to an outbreak of reactive oxygen species，but in severe cases， it can further cause mitochondrial oxidative membrane rupture and death， known as “Mitoxyperilysis”. This article systematically reviewed the signaling network of AIV-activated mitophagy，focusing on the interaction between viral proteins and core autophagy components， and deeply explored the oxidative stress， lipid peroxidation， and "Mitoxyperilysis” effects caused by mitophagy dysfunction， aiming to provide a theoretical basis for the development of new antiviral strategies targeting host mitochondrial homeostasis.

Keywords： Avian influenza virus; Cellular autophagy; Mitophagy; Oxidative stress

禽流感是一种由禽流感病毒（Avianinfluenzavirus，AIV）引起的急性、高度接触性呼吸道传染病，在全球范围内呈周期性暴发并对养禽业造成严重的经济损失。（剩余17313字）