选择性BET蛋白抑制剂在心血管疾病中的研究进展及临床潜力

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【Abstract】Cardiovasculardiseasesremainoneof theleadingcausesof mortalityworldwide，ndtheirtreatmentcontinues toface significantchalengsromodomainndetra-tinaldomai（BE）proteiniiosareanemeingthapeticappoachatreglate geneexpressonandhavebenwidelyapliedinthefieldsofcancer，neurologicaldiseases，ndautoimmunediseases.Amongthem， apabetalone，aststoalleletiepoteiniissogeatliicalterapeicotetialinpatintsithdoaslar diseases.Thisarticlesystematicallreviews therelevantprogressofBETproteininhibitors inthefieldofcardiovasculardiseases.

【Keywords】Cardiovasculardisease；Bromodomainandextra-terminaldomainproteininhibitor；Apabetalone；Inflammation; Lipidmetabolism

心血管疾病（cardiovasculardisease，CVD）是全球发病率和死亡率最高的疾病之一，动脉粥样硬化血栓形成作为其核心病理机制，涉及慢性炎症、内皮功能障碍、脂代谢紊乱及凝血系统失衡等多重机制的复杂交互[1]。（剩余12534字）