丝胶蛋白在生物医用材料中的研究进展与展望

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中图分类号：TS101.9；TP242.2 文献标志码：ADOI：10.13338/j.issn.1006-8341.2025.03.001

引文格式：.丝胶蛋白在生物医用材料中的研究进展与展望[J].纺织高校基础科学学报，2025，38（3）：1-13.YANG Meng，WANG Yongchao，LAN Guangqian. Research progress and prospect of sericin in biomedicalmaterials[J].Basic Sciences Journal of Textile Universities，2O25，38（3）：1-13.

Abstract Sericin protein，a vital natural macromolecular component of silk， has demonstrated substantial potential in biomedical materials owing to its exceptional biocompatibility，cel-adhesive properties， tunable degradation kinetics，and abundant active functional groups enabling facile modification. This review systematically delineates the core characteristics of sericin as a biomaterial and critically analyzes the advantages，limitations，and technical bottlenecks of primary extraction methodologies. Emphasis is placed on the development and applications of diversified sericinbased material formats，including hydrogels，films， nerve conduits，scaffolds，microneedles，microspheres，and flexible wearable electronics in tissue engineering and regenerative medicine. Future research directions encompass： developing mild and efficient extraction techniques，elucidating structure-function relationships of bioactive sericin peptides，enhancing mechanical properties through nanocomposite strategies， advancing exploration of smart-responsive materials，3Dprinted bioinks，and implantable electronics，and facilitating the transition of sericin from a textile byproduct to a high-value-added biomaterial.

Keywordssericin protein; biomedical application; tissue engineering; regenerative medicine

0 引言

蚕丝是由家蚕（bombyxmori）丝腺分泌的天然蛋白质纤维，其生产周期短且具有生物节律特征，作为人类最早开发的生物材料之一，已在文明进程中持续应用数千年[1-3]。（剩余29101字）