清金化痰汤加减联合阿奇霉素序贯疗法治疗痰热壅肺型儿童重症肺炎支原体肺炎临床研究

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[关键词］重症肺炎支原体肺炎；儿童；痰热壅肺证；清金化痰汤；阿奇霉素序贯疗法；免疫功能 [中图分类号]R725.6；R272 ［文献标志码］A [文章编号]0256-7415（2025）23-0001-06 DOl:10.13457/j.cnki.jncm.2025.23.001

Clinical Study on Modified Qingjin Huatan Decoction Combined with Azithromycin Sequencial Therapy in the Treatment of Severe Mycoplasma Pneumoniae Pneumonia of Phlegm-Heat Obstructing the Lung Type in Children

ZHAO Chuangqi，ZHAO Yanchao，TAO Juan Department of Pediatrics，Pingdingshan HospitalofTraditional Chinese Medicine，Pingdingshan Henan467ooo，China Abstract：Objective：To observe the clinical efficacy of modified Qingjin Huatan Decoction combined with

Azithromycin sequential therapy inthe treatment of severe mycoplasma pneumoniae pneumonia（SMPP）of phlegm-heat

obstructing thelung type in children on the basis of the conventional symptomatic treatment.Methods:A total of 88

pediatric patientswith SMPPof phlegm-heat obstructing the lung typeadmited to the Department of Pediatrics,

Pingdingshan Hospitalof Traditional Chinese Medicine from October 2022 to October 2O24 were selectedand divided

into the observation group and the control group using the random number table method，with 44 cases in each group. Both groups received conventional symptomatic treatment.The control group was treated with Azithromycin sequential therapy basedonsuch regimen，whilethe observation group was treated with modified Qingjin Huatan Decoctionon the basis of thecontrol group's regimen.The treatment course for both groups covered12 days.The clinical efficacy, symptomand sign relief time，as wellas the humoral immune indicators [immunoglobulin(Ig）A，IgG，IgM]，and cellular immune indicators （CD3+， CD4+ ， CD4+/CD8+ ）before and after treatment were compared between the two groups.The safty during treatment was recorded.Results:After treatment，the total efectiverate inthe observation group was 95.45% （42/44），which was higher than 79.55% （35/44） in the control group （ P ，expectoration，and pulmonary rales in the observation group were shorter than those in the control group（ P0.05 ). After treatment，the levels of CD3+ ， CD4+ ，and CD4+/CD8 + value were increased in both groups compared with those before treatment ( P+ ，CD4 ⋅+ ，and CD4+/CD8 + value in the observation group were higher than those in the control group ( P

Keywords:Severe mycoplasma pneumoniae pneumonia； Children；Phlegm-heat obstructing the lung syndrome; Qingjin Huatan Decoction；Azithromycin sequential therapy；Immune function

近年来，重症肺炎支原体肺炎(SMPP)的发病率呈逐年上升趋势，该病可引起严重肺内损害，累及多个肺外系统，造成肝损害、心肌损害等相关严重肺外并发症。（剩余11710字）