芳香醒脑开窍中药对全身麻醉后促醒作用的网络药理学机制研究

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关键词：麝香；冰片；促醒；芳香醒脑开窍；全身麻醉；网络药理学；分子对接中图分类号：R285 文献标志码：A 文章编号：1007-3213（2026）03-0751-10DOI：10.13359/j.cnki. gzxbtcm.2026.03.028

A Network Pharmacology Study on Aromatic Herb for Inducing Resuscitation After General Anesthesia

CHEN Zhuoqing'，YI Han1，CHEN Yao²

eFifthSchoolofClinical Medicine，Guangzhou UniversityofChinese Medicine，Guangzhou 510o95Guangdong，China; 2.Guangdong Second Traditional Chinese Medicine Hospital，Guangzhou 510095 Guangdong，China）

Abstract：Objective To investigate the mechanism of Moschus and Borneolum Syntheticum in promoting recovery fromanesthesia using network pharmacology.Methods Active ingredients and corresponding targets of Moschus and Borneolum Syntheticum were collcted from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）and HERB.Anesthesia-related targets were retrieved from the GeneCards and OMIM databases.The intersection of drug targets and disease targets was identified using the Venny 2.1 online platform.The STRING database，Cytoscape 3.9.2 software，and the Microbioinformatics platform were employed to construct aprotein-protein interaction（PPI）network and to perform Gene Ontology（GO）functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway enrichment analysis.Results A total of 110 active ingredients were identified in Moschus and Bormeolum Syntheticum.Key active ingredients included baicalein，testosterone，pinosylvin，N-demethylnuciferine，etc.，which mainly acted on core targets such as SRC，STAT3， HSP90AA1，AKT1，and GABRA1， involving signaling pathways such as neuroactive ligandreceptor interaction，calcium signaling pathway，and serotonergic synapse.Molecular docking demonstrated favorable binding activity between the major active ingredients and the core targets.Conclusion Moschus and Borneolum Syntheticum may exert their awakening-promoting efects after anesthesia through a multi-component， multi-target，and multi-pathway synergistic mechanism.This is likely mediated byactive ingredients suchas baicalein，testosterone，pinosylvin，and N-demethylnuciferine，acting on core targets including SRC，STAT3， HSP90AA1，AKT1，and GABRA1，and regulating signaling pathways such as neuroactive ligand-receptor interaction， calcium signaling，and serotonergic synapse.

Keywords：Moschus；Borneolum Syntheticum；resuscitation；aromatic herb for inducing resuscitation；general anesthesia；network pharmacology；molecular docking

静脉注射全身麻醉无痛技术，因其药物种类需求简约、操作流程简便以及患者高接受度等显著优势，是胃肠镜检查和门诊手术中常用的麻醉方法。（剩余13891字）