基于光电容积脉搏波的连续血红蛋白测量方法实验研究

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【中图分类号】R-33 【文献标志码】A

Continuous hemoglobin measurement based on photoplethysmography ： an experimental study

Zhao Long'，Peng Ling²，Zhang Xue2 ，Zhang Yi2 ，Huang Yucheng³，Jiang Hao 3 ，LinZhibin³，GaoBo³，WeiWei² （1.Department of Cardiac Vascular Surgery，The Third People's Hospital of Chengdu;2. Department of Anesthesiology，West China Hospital，Sichuan University;3.Collegeof Physics，Sichuan University） 【AbstractObectiveTvestigate thefeasibilityofdescendigaorticphotoplethysmogaphyPPG）inthemeasurementofoglobin （pHb）.Methods：Atotalof17experimentalpigs withanageof3-5monthsandaweightof30-5Okgwereselected.Afteranesthsia induction，areflectancePGprobeasinsertedintothsophagus todetectchracteristicdescendingorticPGsigal.Temethod ofhemodilutionwasusedtoestablishthegradientchangesofthereductioninhemoglobin（Hb），andthemethodoftansfusionwassed toestablishthegradientchangesoftheincreaseinHb.TwomiutePGsignalwascolectedforeachgradienttopirwithtecoe sponding hemoglobin reference value（ Hbref ）measured by blood gas analysis and establish a correlation dataset.A program was written in MatlabtoetractalternatingcomponentanddiectcomponentforbothedandinfraredlightsinPGsignal，hichwasintroduced intoafedforwardralworkodeltoba.Theeaegresioanalysis，and-lanplotndPolarloalise used to evaluate the consistency between pHb and Hbref .The error grid analysis was also used to assess the clinical significance of pHb measurementror.Results：eescendingaoicPGsignalwassucfullyetectdinallexperimntalpigsintisstdylinear correlation coefficient between pHb and Hbref was 0.81（ P <0.01），with a relatively small bias （0.6 g/L ）and a wide limit of agreement -20.49 to 21.69g/L ），and the consistency rate of trend ability was 59.3% . The Clark error grid analysis showed that 83% of the data were distributed within the Zone A，16% within the Zone B，and 0% within the Zone C.Conclusion：Itis feasible to establish a continuous pHb trend measurement based on descending aortic PPG signal，and there is a moderate corelation between pHb and Hbref

Continuous pHb measurements may be used a potential trend prediction toolto facilitate clinical decision-making.This animal study providesan experimental foundationforthedevelopmentofbedside continuous pHb monitoring in the future.

【Keywords】 photoplethysmography；hemoglobin；descending aorta;neural network

光电容积脉搏波（photoplethysmography，PPG）是发光二极管照射具有搏动血容量的组织如手指、脚趾、耳垂等，记录随心脏搏动所引起监测部位血容量周期性变化而产生的光吸收值变化，并将这种光吸收信号转换为电信号。（剩余12427字）