肿瘤相关成纤维细胞源性外泌体调控肿瘤耐药机制的研究进展

打开文本图片集

【中图分类号】R34 【文献标志码】A

Research advances in the mechanism exosomes derived from cancer-associated fibroblasts in regulating tumor drug resistance

Wu Jiafan，Liu Yuan，Huang Wenwen，Li Xiao，Wang Xinyu，Li Ruhong （ ， ， ） 【Abstractmicroenvironment，asthindispensableinteralevironentfotumorcels，playsapivotaloleintumortrapy drugresistance.Cancerasocatedfibrblasts（CAF）canremodeltheextracelularmatrix，creteslubleacrsadreleasetracelularvesics，erebygulatingteiologicalprocsstumrsecigthrugesistanetumos.Astetacular vesiclesreleasedbyCAF，CAF-derivedexosomes（CDE）hasbecomeakeylinkinexpingtheresearchfieldCAF，itcanaffectheprocesstumordevelopmentprogresionplayanimportantroleintheformationtumordrugresistanceceotherapyndradiotherapyThisarticlereviews theroleCAFCDEintumordrugresistance，elaboratesonthespecificregulary mechanismsCDEintheformationdrugresistanceindiferenttypestumor，discussestheapplicationperspectives CDE in inhibiting the formation drug resistance in tumors.

【 words】cancer-associated fibroblasts ;exosomes;drug resistance;tumor cell

肿瘤微环境（tumormicroenvironment，TME）是肿瘤细胞生存的内环境，对肿瘤治疗和耐药至关重要。（剩余16044字）