放疗联合免疫治疗驱动基因阴性非小细胞肺癌：进展与挑战

打开文本图片集

【中图分类号】R734.2 【文献标志码】A

Radiotherapycombined with immunotherapyin treatment of driver gene-negative non-small cell lung cancer： updates and challenges

DuJia，LiMengxia，ChenChuan （Department of Oncology，Daping Hospital，Army Medical University） 【Abstract】Non-smallcellung cancer（NSCLC），as the most common type of lung cancer，accounts for approximately 85% of primary lungcancercases，hilethereareoftenlimitedtreatmentoptionsfordrivergene-negativeNSCLC.Inrecentyears，thecombinationof radiotherapyandimmunotherapyhas emergedasanoveltreatmentstrategyfordriver gene-negativeNSCLC，demonstratingthe potentialtoimprovesurvivalratesandtreatmentoutcomes.Thisarticlereviewsthbiologicalmechanismsofradiotherapycombinedwithimmunotherapyandtheclinicalapplicationof thismethodidrivergene-negativeNSCCanddisussesrelatedchalenges，inderto provide a reference for clinical practice.

【Key words】non-smallcellung cancer;driver gene-negative;radiotherapy;immunotherapy;research advances

最新癌症统计数据显示，2022年全球肺癌新发病例约248.1万例，死亡病例约181.7万例。（剩余23586字）