中药抗氧化应激治疗血管性痴呆的药理学研究进展

打开文本图片集

中图分类号R749.13

【文献标志码】A

Advances in pharmacological research on traditional Chinese medicine for anti-oxidative stresstreatmentofvasculardementia

Zhang Xinyue'，SongLin2，Wu Weidong'，ZhaoTengyu'，PanPengyu’，Zou Mingyue'，Zhou Yuhan'，Zhou Yanyan’ （1.School of Basic Medicine，Teaching and Research Section of Basic Theory of Traditional Chinese Medicine，

Heilongjiang UniversityofChinese Medicine;2.SchoolofLifeSciences，Huizhou University;3.LaboratoryofBasic Theory Research of Traditional Chinese Medicine，Heilongjiang Provincial Key Laboratory， Heilongjiang University of Chinese Medicine）

【AbstractlOxidativestress（OS）runsthroughtheentirepathogenesisprocessofvasculardementia（VaD），anditis intricatelyinter twinedandcloselyoiatedwithotherpathogenicmechansmssuchasdyfunctionoferebralendothlialcels，lood-abarer damage，itsoisopcsdtsrel used as an important means to improve VaD. Drugs such as 1-amino- 3，5 -dimethyladamantamine hydrochloride and donepezil hydrochloridearecommonlyusedfirst-linedrugsforthetreatmentofVaDinclinicalpractice，andalthoughtheyhaveacertainffectin clinicalppication，theyalsohavesomesideefects.Comparedwith Westernmedicine，traditionalChinesemedicineemphasizesthe coordinatedregulationofmultiplevisceraandbowelsandtheconceptofsyndromediferentiationbasedtreatment，whichhighly conforms totheclinicalsymptomsofVaD，andtraditional Chinese medicinecanimprove VaDbyvarious meanssuchasscavenging freeradicals，inhibitinglipidperoxidation，andregulatingOS-relatedsignalingpathways.Thisarticlereviewsthepharmacological studiesonhowtraditional Chinese medicine improves VaDbyregulatingOSinthepastfiveyearsandsummarizesthepharmacological mechanisms by which OS affects VaD，inorder to providea basis for subsequent clinical research.

【Keywordsvasculardementia;xidativestress;monomersofChinese herbs;compoundtraditionalChinese medicineprescriptions

血管性痴呆（vasculardementia，VaD）是一种以学习、记忆力下降，认知功能障碍等为主要临床表现的一种脑区低灌注的脑血管疾病。（剩余20163字）