肠道菌群和DNA甲基化在生命早期运动对成年期糖脂代谢影响中的作用

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【中图分类号】R589【文献标志码】A

The role of gut microbiota and DNA methylation in the effect of early-life exercise on glucolipid metabolism in adulthood

Li Shunhua'，Zhou Liyuan²，Ren Jingl，Zhang Qian'，Xiao Xinhua'

（1.KeyLaboratoryofEndocrinologyofNational HealthCommission，Diabetes Research CenterofChineseAcademy

ofMedicalciences，DepartmentofEndocrinologyekingUnionedicalColegeHospital，ekingUniondical Collge，Chinese Academy of Medical Sciences;2.Departmentof Endocrinology，Beijing Chaoyang Hospital， Capital Medical University）

【AbstractChronic metabolicdisorderssuchas diabetesandobesityhaveemergedas major global healthchalenges.Adverse ntrauterineenvironmentduringarlylifesignificantlyincreases tesusceptibilitytometabolicdiseasesinadutood.Matealexeciseinterventiohasbeenrecognizedasaneffctivemeasuretoimproveglucolipidmetabolichealthinofspring；however，theunderlying mechanismremainsunclear.Gut microbiota hasbecomearesearch hotspot in this field.Recent evidencehasshow thatgut microbiota-derivedmetabolitesmayinfluencehostDNAmethylationbyprovidingmethyldonors.Thisarticleaims toclarifyheprotec tiveeffctofearly-lifeexerciseinterventiononintergenerationalmetabolismfromtheperspectiveofthe“gutmicrobiota-gut microbiota-dredmeabolites-Detylatio”axis，idertprovideewtorecalassdpotentialintervetoatr disrupting the intergenerational transmission of glucolipid metabolic disorders.

【Key wordsearly-lifeexercise;utmicrobiota;DNA methylation;gutmicrobiota-derivedmetabolites;lucolipid metabolism

据国际糖尿病联盟最新发布的糖尿病地图显示，当前全球约5.37亿糖尿病患者，预计到2050年将激增近1.5倍[。（剩余19816字）