孕期运动改善子代糖脂代谢的表观遗传学机制探讨

【中图分类号】R589

【文献标志码】A

The epigenetic mechanism by which maternal exercise during pregnancy improves glucose and lipid metabolism in offspring

Ren Jing'，Zhou Liyuan²，Zhang Qian'，Xiao Xinhua'

（1.Key Laboratoryof EndocrinologyofNational Health Commission，Diabetes Research Centerof Chinese Academy

ofMedicalSciences，DepartmentofEndocrinology，Peking UnionMedicalColegeHospital，PekingUnionMedical Collge， Chinese Academy of Medical Sciences;2.Department of Endocrinology，Beijing Chaoyang Hospital， Capital Medical University）

【Abstract]Metabolicdiseasesare becomingaglobalpandemic，ndadverse maternal metabolicconditions duringpregnancycanincreasethelong-termriskofmetabolicdiseaseinofspringviadevelopmentalprogramming.Studieshaveshownthatregularmaternal exercisenotonlyimproesmatealhealthbutalsosignificantlyimprovesgucoseandlipidmetabolisminfspring，andsuchprotec tiveefectcanlastilladulthoodEpigenetiprogammingiskeyunderlgmehansm.Matealexeisecareveseigeneticmodifcatiosiducedbydveseitrauterieviroent，nludngethylatio，istoodification，ndoing RNA.This articlereviews theepigeneticmechanisms bywhich maternal exercise during pregnancyimprovesofspring metabolic health，aiming to provide new perspectives for early-life interventionin metabolic diseases.

【Key words】maternal exercise;offspring;glucose and lipid metabolism;epigenetics

代谢性疾病，特别是2型糖尿病（type2diabetes，T2D）和肥胖症，正以惊人的速度演变为全球性健康危机。（剩余26226字）