妊娠期糖尿病产后2型糖尿病转归的血浆脂质代谢物研究进展

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【中图分类号】R587.1 【文献标志码】A

Research advances in plasma lipid metabolites for predicting the progression of gestational diabetes mellitus to postpartum type 2 diabetes mellitus

ZhangShenrui’，Xiao Xinhua²，ZhengJia' （1.DepartmentofEndocrinologyPeking UniversityFirstHospital;2.KeyLaboratoryofEndocrinologyofNational Health Commision，Diabetes Research Center of Chinese Academyof Medical Sciences，Departmentof Endocrinology， Peking UnionMedical CollegeHospital，Peking UnionMedicalCollege，ChineseAcademyofMedical Sciences） 【Abstract】Gestational diabetesmelitus（D）isoneof themostcommonpregnancycomplications，anditsincidencehasben graduallyincreasingyearbyyear.GDMisanindependentriskfactorforadversepregnancyoutcomesandhasalongteimpacton thehealthofbothmothersandtheirofspring.ThehistoryofGDMcansignificantlyincreasetheriskoftype2diabetesmlits （T2DM）inwomenadalhoughseveraliskfactorshavebnidentifid，hereisstillalackofrlywaiginicatorforepo gresiontoTDMinpatintswithGDM.Therefore，itisurgentlyeededtodiscovernoveliomarkersforpredicting teiskofostpar tumT2DMinGDMpatients，therebyidentifingthepopulationataighiskofdabetesasearlyaspossible.Inrecentyears，ipido mics，animportantbranchofmetabolomics，hasshownuniqueadvantagesindeterminingovelbiomarkersfortheriskofpostpartum T2DMthroughhigh-throughputasessmentofsmall-moleculelipidprofile.Thisarticlesystematicallyelabratesontheadvaces in theapplicationoflpidomictechniquesinteabovefeldandsummarizesteresearchfindingsofnovelipid-basedomarkrsino dertoprovidateoreticalframeworkfordiscoveringinterventiontargetsforGDManddevelopingprecisetreatmentstrategisbased on lipidomics.

【Key words】gestational diabetes melitus;type 2 diabetes mellitus;lipidomics ;postpartum progression

妊娠期糖尿病（gestationaldiabetesmellitus，GDM）是妊娠期首次发生的糖代谢异常，不包括孕前已经存在的糖尿病或糖尿病前期[1-2]。（剩余13691字）