【摘 要】 目的：在北京市城市某社区1986年和1997年两次调查的基础上，调查2004年老年期痴呆患病率水平及其相关因素，并分析近20年的变化特点。方法：整群抽取北京市城市某社区1562名65岁及其以上老人为调查对象，采用国际痴呆合作项目（10/66）全套神经心理学评估方法进行测试，按照ICD-10研究用诊断标准进行病例诊断。结果：2004年该社区调查65岁及其以上人群老年期痴呆患病率为4.1%（48/1160），与1997年调查所获患病率3.2%相比差异无显著性（P=0.688）。三次调查中、重度老年期痴呆患病率比较差异无显著性（2.8%，1.9%，1.8%，P=0.192）；患病率均随年龄增长有增加趋势（2004年调查：65-69岁，1.6%；70-79岁，3.0%；≥80岁，11.0%）。阿尔茨海默病、血管性痴呆2004年调查分别为47.9%、45.8%（χ2=0.04，P=0.838），而1997年调查为57.9%、34.2%（χ2=4.29，P=0.038）。结论：该社区近20年三次调查结果显示老年期痴呆患病率水平相对稳定，随着年龄增长而增加。
【关键词】 痴呆； 阿尔茨海默病；血管性痴呆； 患病率；流行病学调查
中图分类号：R749.16、R181.32 文献标识码：A 文章编号：1000-6729(2008)002-0110-04
Longitudinal Study on Dementia in an Urban Community of Beijing City in Two Decades
YAN Fang1, LI Shu-Ran1, HUANG Yue-Qin1, et al.
Institute of Mental Health, Peking University, Beijing 100083
【Abstract】 Objective: To investigate prevalence of dementia and related factors among people aged 65 and over in an urban of Beijing City based on two surveys carried out in the same area both in 1986 and 1997, and to analyze the dynamic change of dementia prevalence in the past two decades. Methods: Using cluster sampling, 1562 elderly aged 65 orand overabove were interviewed by a set of fully structured assessments in a one-stage process developed by the 10/66 group for dementia in an urban district of Beijing City. Dementia patients were diagnosed in accordance with ICD-10 criteria. Results:The prevalence rate of dementia among the elderly people in 2004 was 4.1%, which was similar to 1997's result (3.2%, ). There wereno statistical differences among the three surveys on prevalence of moderate and severe dementia（2.8%，1.9%，and 1.8% respectively,P=0.192）. The prevalence rates of dementia were increased with age.In 2004, the patients with AD were much more than those with VD (47.9%/45.8%). Conclusions:The three surveys in the same district during two decades show that the level of dementia prevalence is rather stable. The prevalence of dementia increased with age.
【Key words】 dementia;alzheimer's disease ;vascular dementia;prevalence; epidimiology survey
全世界人口老龄化的速度平稳增加，且快于预期速度。（剩余906字）