【摘要】 目的 研究黄精多糖对H22实体瘤、S180腹水瘤的生长抑制作用和对荷瘤小鼠免疫调节作用。方法 小鼠接种H22实体瘤或S180腹水瘤后随机分组,灌胃给予不同剂量［100、200、400 mg/(kg·d)］的黄精多糖,以生理盐水和环磷酰胺为空白对照组和阳性对照组，计算黄精多糖对小鼠H22实体瘤生长的抑制率，脾脏指数和胸腺指数，以及S180腹水型荷瘤小鼠的存活时间。结果给予黄精多糖灌胃的荷瘤小鼠的脾脏指数和胸腺指数显著增加；低、中、高剂量的黄精多糖对H22实体瘤的抑瘤率分别是(34.93、43.44、56.25)%；中、高剂量的黄精多糖可以显著延长S180腹水型荷瘤小鼠的存活时间。结论 黄精多糖有显著的抗肿瘤作用和免疫调节活性。
【关键词】 黄精多糖；抗肿瘤作用；免疫调节
【Abstract】 Objective To study the anti-tumor activity of polygonati polysaccharide on H22orS180 tumor mice, and the immunoregulation effect on H22 tumor mice. Methods H22orS180 tumor mice were administered orally with 100,200,400 mg/(kg·d) dosage of polygonati polysaccharide, then the tumor inhibition rate, life time, thymus index, spleen index were measured. Results Polygonati polysaccharide can increasethe thymus index and spleen index, and the tumor inhibition rate was (34.93、43.44、56.25)%,respectively. Moreover, polygonati polysaccharide can evidently prolong life time of S180 tumor mice. Conclusion Polygonati polysaccharide showed obviously anti-tumor activity and immunoregulation effect.
【Key words】 Polygonati polysaccharide; Anti-tumor activity; Immunoregulation effect
黄精(Rhizoma polygonati)为百合科植物滇黄精、黄精或多花黄精的干燥根茎，具有补气养阴、健脾、润肺、益肾之功效［1］。（剩余1413字）