[摘要]目的探讨补肾方、活血方、补肾活血方对血管性痴呆小鼠学习记忆能力的影响。方法采用脑缺血再灌注的方法复制血管性痴呆小鼠模型，观察补肾方、活血方、补肾活血方各组小鼠水迷宫法行为学的影响。结果与假手术组比较，模型小鼠学习与记忆能力下降，表现为游全程时间延长，错误次数增加（P<0.01）；与模型组比较，各治疗组学习成绩和记忆成绩均有提高，差异有显著性（P<0.01），补肾活血组的学习成绩与记忆成绩优于其它治疗组（P<0.01），补肾组在记忆成绩优于活血组（P<0.05），活血组在学习成绩优于补肾组（P<0.05）。结论补肾中药、活血中药、补肾活血中药对血管性痴呆小鼠学习与记忆能力下降均有提高作用，对于长期记忆的改善作用补肾中药优于活血中药，对于短期学习能力的改善作用活血中药优于补肾中药，补肾中药与活血中药具有协同作用。
关键词：血管性痴呆 小鼠 行为学 中药
The effect of bushenfang, huoxuefang, and bushenhuoxuefang on ability of learning and memory of vascular dementia mouse Lishiying ,Handan traditional chinese medical hospital,Handan 056001
[Abstract]Objective： To probe the effect of bushenfang, huoxuefang, and bushenhuoxuefang on ability of learning and memory of vascular dementia mouse. Methods： To reproduct the mouse model of vascular dementia through operation of cerebral ischemia reperfusion, and observe the praxiological changes of bushenfang, huoxuefang, and bushenhuoxuefang group mouse by the means of water maze. Results： Compared with normal group, the ability of vascular dementia model mouse for learning and memory reduced, which showed extending the time for swimming the whole process, and increasing times of mistakes（P<0.01）.Compared with model group, the learning and memorizing performance record of each treatment group were improved (P<0.01). The learning and memorizing performance record of bushenhuoxuefang group were excellent than other treatment group（P<0.01）.The memorizing performance record of bushenfang group were excellent than other group（P<0.05）.The learning performance record of huoxuefang group were excellent than bushenfang group（P<0.05）. Conclusion： The bushen, huoxue , and bushenhuoxue traditional Chinese medicine can improve the learning and memory capability. .The longterm memorizing ability of bushen traditional Chinese medicine were excellent than huoxue traditional Chinese medicine（P<0.05）.The shorterm learning ability of huoxue traditional Chinese medicine were excellent than bushen traditional Chinese medicine（P<0.05）,the two kind of traditional Chinese medicine has synergistic action.
[Key word]Vascular dementia; Mouse; Praxiolopy; traditional Chinese medicine
中图分类号：R749.79 文献标识码：B 文章编号：1672-5085（2007）1-0043-02
血管性痴呆（VD）是因脑血管病所致的智能及认知障碍，补肾类、活血类中药治疗VD具有公认的疗效[1]，但临床所用复方多为多种治法综合而成，为了探讨不同治法对于VD的作用效果及其协同关系，本研究采用反复脑缺血再灌注的方法复制血管性痴呆小鼠模型，观察补肾类中药、活血类中药、补肾活血类中药对模型小鼠行为学的影响，现报道如下。（剩余660字）