[摘要] 目的：检测肝硬化患者血清叶酸水平，观察血清叶酸水平与肝硬化的相关性，探讨叶酸在肝硬化诊断中的价值。方法：采用免疫化学发光法对59例肝硬化患者、42例非肝硬化患者及50例健康体检者的血清叶酸水平进行检测。结果：肝硬化患者血清叶酸水平显著低于非肝硬化患者和健康体检者，均有统计学意义（分别为P<0.05，P<0.01），肝硬化伴腹腔积液患者叶酸水平更低，且与肝硬化伴腹腔积液患者叶酸水平比较有显著性差异(P<0.01)。与清蛋白、丁酰胆碱酯酶、凝血酶原活动度等反映肝组织病理损伤程度和肝纤维化进程指标具有良好正相关性（相关系数r分别为0.768 1,0.892 3,0.821 0）。结论：肝硬化患者FA水平显著降低，与肝纤维化的病理进程密切相关，血清FA水平检测将成为有价值的肝硬化诊断指标，对肝硬化的发生、发展及疗效和预后具有十分重要的临床意义。
[关键词] 叶酸；肝硬化；清蛋白；丁酰胆碱酯酶；凝血酶原活动度
[中图分类号] R575.2 [文献标识码]B [文章编号]1673-7210（2008）02（a）-025-02
The correlalivity study between the level of serum FA and cirrhosis
YU Xiu-wen,LI Zhi-feng,SUN Tao,GAO Hong-mei
(Zaozhuang Hospital of Zaozhuang mining group,Zaozhuang 277101,China)
[Abstract] Objective:Testing serum folic acid levels in patients with liver cirrhosis observed serum folic acid levels and the relevance of cirrhosis, liver cirrhosis of folic acid in the diagnosis of value.Methods: Immune chemiluminescence on 59 cases of patients with cirrhosis, 42 cases of non-cirrhotic patients with liver disease and 50 cases of physical examination, serum folate levels were detected.Results: Serum folate of cirrhotic patients was significantly lower than that of non-cirrhotic liver disease patients and healthy controls, both with statistical significance(P<0.05, P<0.01), liver cirrhosis mix at lower levels of folic acid in patients with ascites, and in patients with liver cirrhosis and ascites mixing folic acid compared the difference was significant (P<0.01), and albumin, butyrylcholinesterase, prothrombin activity, and other pathological liver tissue injury to reflect the degree of liver fibrosis and had a good process indicators and a positive correlation (r=0.768 1,0.892 3,0.821 0).Conclusion:Cirrhotic patients have significantly lower FA, and liver fibrosis is closely related to the pathological process, the level of serum FA will be valuable indicator of cirrhosis of the liver sclerosis, development and efficacy and the prognosis is of great clinical significance.
[Key words] Folic acid;Cirrhosis;Albumin;BCHE;PTA
有研究发现,肝硬化时血清FA水平显著低于正常对照组[1]，认为FA水平可作为肝损伤的诊断指标。（剩余928字）