【摘要】目的：探讨p63在乳腺良、恶性疾病中的表达及意义。方法：收集乳腺良、恶性疾病的石蜡包埋标本50例（纤维腺瘤，纤维囊性病，导管内乳头状瘤，导管内癌，浸润性导管癌和浸润性小叶癌）采用免疫组化S-P法检测p63在上述病变中的表达。结果：在乳腺良性病变中几乎所有的腺体外周都见完整的p63阳性的肌上皮围绕；在导管内癌中，部分导管外围可见完整的p63阳性的肌上皮围绕（24％），部分导管外周p63阳性的肌上皮细胞则呈间断性分布（62％），甚至无肌上皮细胞（14％）；在浸润性癌的癌细胞巢外周未见p63阳性的肌上皮细胞。结论：p63作为肌上皮细胞的标记物有助于在疑难的乳腺病变中正确识别肌上皮细胞，鉴别良恶性病变。
【关键词】乳腺疾病；免疫组织化学；p63
文章编号：1009-5519（2007）22-3341-02 中图分类号：R36 文献标识码：A
Role of p63 in differential diagnosis of epithelial benign and m alignant breast lesions
DENG Xing-hui，YU Wei-dong，ZHOU Wei
（The Central Hospital of Jiangmen，Guangdong 529030，China)
【Abstract】Objective：To study the role of p63 in differential diagnosis of epithelial benign and m alignant breast lesions. Methods：We collected 50 cases of breast benign and m alignant paraffin-embedded samples(including fibroadenoma，fibrocystic diseases，intraductal papilloma，intraductal caicinoma，invasive ductal carcinoma and invasive lobular carcinoma)，and detected the expression of p63 in above breast lesions by immunohistochemistry.Results：In breast benign lesions，almost all of the glands were encircled by p63 positive cells. In intraductal carcinoma，some cancer cell nests(24%) showed continuous positive cells in their circumference；other showed discontinuous or even no positive cells (62% and 14% respectively) .There were no p63 positive cells in invasive carcinomas. Conclusion：As a marker of myoepithelial cells，p63 could help to recognize myoepithelial cells correctly in confusing breast lesions and differentiate epithelial benign from m alignant breast lesions.
【Key words】Breast disease；Immunohistochemistry；P63
肌上皮细胞（myoepithelial cells， MECs）构成乳腺上皮结构的基底细胞层，在乳腺良性增生性病变中，腺体周围MECs存在，而在恶性病变出现浸润时MECs消失，因此MECs存在与否对乳腺良、恶性病变的鉴别诊断具有重要的价值。（剩余1405字）